Afife Nurbanu Sultan was Haseki Sultan of Ottoman as principal consort and legal wife of Sultan Selim II and Valide Sultan of Ottoman as mother of Sultan Murad III. Conflicting theories ascribe her a Venetian, Jewish or Greek origin. Her birth name may have been Cecilia Venier-Baffo, Rachel or Kalē Kartanou. Nurbanu was one of the prominent figure during the era known as Sultanate of Women.
After Nurbanu became the valide sultan to her son Murad III, she effectively managed the government together with the Grand Vizier Sokollu Mehmed Pasha, who acted as co-regent with the sultan during the Sultanate of Women. Her intermediary to the world outside the harem was her "kira", Esther Handali. "Kira" was so popular means of communication with the outside world when Nûr-Banû was the Valide Sultan that the two women were said to have been lovers. She corresponded with the queen Catherine de' Medici of France. Venetian accounts are the most prolific in describing Nurbanu Sultan as a woman who never forgot her Venetian origins.
During her nine years of regency (1574–1583), her politics were so pro-Venetian that she was hated by the Republic of Genoa. Some have even suggested that she was poisoned by a Genoese agent. In any case, she died at the palace in the Yenikapı Quarter, Istanbul on 7 December 1583. Moreover, it has been said that Nurbanu was related to Safiye Sultan, who was born Sofia Baffo, married Murad III, and consequently became the next valide sultan of the Ottoman Empire when her own son Mehmed III acceded to the throne. On the other hand, the Ottoman records claim that the Republic of Venice became highly dependent on the Ottoman Empire during the regency of Nurbanu because her policies were allegedly extremely pro-Jewish.
https://en.wikipedia.org/wiki/Nurbanu_Sultan
https://en.wikipedia.org/wiki/Esther_Handali
https://en.wikipedia.org/wiki/Safiye_Sultan
https://en.wikipedia.org/wiki/Esperanza_Malchi
https://en.wikipedia.org/wiki/Catherine_de'_Medici
http://www.jewishvirtuallibrary.org/jso…/History/medici.html

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